[HTML][HTML] Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-κB and NF-κB-regulated gene expression through direct inhibition of IκBα kinase β on cysteine 179 …
Although butein (3, 4, 2′, 4′-tetrahydroxychalcone) is known to exhibit anti-inflammatory,
anti-cancer, and anti-fibrogenic activities, very little is known about its mechanism of action.
Because numerous effects modulated by butein can be linked to interference with the NF-κB
pathway, we investigated in detail the effect of this chalcone on NF-κB activity. As examined
by DNA binding, we found that butein suppressed tumor necrosis factor (TNF)-induced NF-
κB activation in a dose-and time-dependent manner; suppressed the NF-κB activation …
anti-cancer, and anti-fibrogenic activities, very little is known about its mechanism of action.
Because numerous effects modulated by butein can be linked to interference with the NF-κB
pathway, we investigated in detail the effect of this chalcone on NF-κB activity. As examined
by DNA binding, we found that butein suppressed tumor necrosis factor (TNF)-induced NF-
κB activation in a dose-and time-dependent manner; suppressed the NF-κB activation …