Molecular imaging of the transcription factor NF-κB, a primary regulator of stress response
H Carlsen, G Alexander, LMI Austenaa… - Mutation Research …, 2004 - Elsevier
A wide range of environmental stress and human disorders involves inappropriate
regulation of NF-κB, including cancers and numerous inflammatory conditions. We have
developed transgenic mice that express luciferase under the control of NF-κB, enabling real-
time non-invasive imaging of NF-κB activity in intact animals. We show that, in the absence
of stimulation, strong, intrinsic luminescence is evident in lymph nodes in the neck region,
thymus, and Peyer's patches. Treating mice with stressors, such as TNF-α, IL-1α, or …
regulation of NF-κB, including cancers and numerous inflammatory conditions. We have
developed transgenic mice that express luciferase under the control of NF-κB, enabling real-
time non-invasive imaging of NF-κB activity in intact animals. We show that, in the absence
of stimulation, strong, intrinsic luminescence is evident in lymph nodes in the neck region,
thymus, and Peyer's patches. Treating mice with stressors, such as TNF-α, IL-1α, or …