Rescuing drug discovery: in vivo systems pathology and systems pharmacology
J van der Greef, RN McBurney - Nature Reviews Drug Discovery, 2005 - nature.com
J van der Greef, RN McBurney
Nature Reviews Drug Discovery, 2005•nature.comThe pharmaceutical industry is currently beleaguered by close scrutiny from the financial
community, regulators and the general public. Productivity, in terms of new drug approvals,
has generally been falling for almost a decade and the safety of a number of highly
successful drugs has recently been brought into question. Here, we discuss whether taking
an in vivo systems approach to drug discovery and development could be the paradigm shift
that rescues the industry.
community, regulators and the general public. Productivity, in terms of new drug approvals,
has generally been falling for almost a decade and the safety of a number of highly
successful drugs has recently been brought into question. Here, we discuss whether taking
an in vivo systems approach to drug discovery and development could be the paradigm shift
that rescues the industry.
Abstract
The pharmaceutical industry is currently beleaguered by close scrutiny from the financial community, regulators and the general public. Productivity, in terms of new drug approvals, has generally been falling for almost a decade and the safety of a number of highly successful drugs has recently been brought into question. Here, we discuss whether taking an in vivo systems approach to drug discovery and development could be the paradigm shift that rescues the industry.
nature.com