Beside the MEF2 axis: unconventional functions of HDAC4
A Clocchiatti, E Di Giorgio, F Demarchi, C Brancolini - Cellular signalling, 2013 - Elsevier
A Clocchiatti, E Di Giorgio, F Demarchi, C Brancolini
Cellular signalling, 2013•ElsevierThe class IIa deacetylase HDAC4 is unequivocally known as a negative regulator of MEF2-
dependent transcription. In the past years several works have allowed us to understand how
different signals, mirroring specific environmental circumstances keep in check the
repressive action of HDAC4 against MEF2s. At the same time, pieces of evidence have
gradually accumulated about HDAC4 activities emancipated from MEF2s. The aim of this
review is to discuss about these “unconventional functions” of HDAC4.
dependent transcription. In the past years several works have allowed us to understand how
different signals, mirroring specific environmental circumstances keep in check the
repressive action of HDAC4 against MEF2s. At the same time, pieces of evidence have
gradually accumulated about HDAC4 activities emancipated from MEF2s. The aim of this
review is to discuss about these “unconventional functions” of HDAC4.
The class IIa deacetylase HDAC4 is unequivocally known as a negative regulator of MEF2-dependent transcription. In the past years several works have allowed us to understand how different signals, mirroring specific environmental circumstances keep in check the repressive action of HDAC4 against MEF2s. At the same time, pieces of evidence have gradually accumulated about HDAC4 activities emancipated from MEF2s. The aim of this review is to discuss about these “unconventional functions” of HDAC4.
Elsevier