Analysis of Genomic Imprinting of Gsα Gene
LS Weinstein, S Yu, J Liu - Methods in enzymology, 2002 - Elsevier
The α subunit of the heterotrimeric G protein G s (G s α) is critical for receptor-stimulated
intracellular cAMP generation. The human and mouse G s α genes (GNAS1 and Gnas,
respectively) are located within syntenic regions at 20q13 in human 1, 2, 3 and distal
chromosome 2 in mouse. 4, 5 Originally these genes were shown to have 13 coding exons
for G s α (Fig. 1), 6 but they are now known to be much more complex, with three additional
promoters and upstream exon regions which generate alternative transcripts by splicing …
intracellular cAMP generation. The human and mouse G s α genes (GNAS1 and Gnas,
respectively) are located within syntenic regions at 20q13 in human 1, 2, 3 and distal
chromosome 2 in mouse. 4, 5 Originally these genes were shown to have 13 coding exons
for G s α (Fig. 1), 6 but they are now known to be much more complex, with three additional
promoters and upstream exon regions which generate alternative transcripts by splicing …