Several members of the multidrug resistance protein (MRP) family are expressed in the liver.
Adenosine triphosphate (ATP)-dependent transport of glutathione and glucuronoside
conjugates across the hepatocyte canalicular membrane is mediated by the apical MRP
isoform, MRP2 (APMRP), also known as canalicular multispecific organic anion transporter
(cMOAT). We have cloned an additional MRP isoform, MRP3, from human liver and
localized it to the basolateral membrane domain of hepatocytes. Basolateral MRP (BLMRP) …