Dual site phospholamban phosphorylation and its physiological relevance in the heart
D Hagemann, RP Xiao - Trends in cardiovascular medicine, 2002 - Elsevier
Phospholamban (PLB) plays a primary role in regulating cardiac sarcoplasmic reticulum
(SR) Ca2+-ATPase activity. Dephosphorylated PLB suppresses the SR Ca2+ pump activity,
whereas phosphorylation of PLB leads to deinhibition. A widely accepted sequential model
of dual site PLB phosphorylation states that PKA-dependent phosphorylation of Ser16 is
obligatory to phosphorylation of Thr17 by Ca2+/calmodulin-dependent kinase II, and mainly
accounts for β-adrenergic receptor mediated cardiac relaxation. However, emerging …
(SR) Ca2+-ATPase activity. Dephosphorylated PLB suppresses the SR Ca2+ pump activity,
whereas phosphorylation of PLB leads to deinhibition. A widely accepted sequential model
of dual site PLB phosphorylation states that PKA-dependent phosphorylation of Ser16 is
obligatory to phosphorylation of Thr17 by Ca2+/calmodulin-dependent kinase II, and mainly
accounts for β-adrenergic receptor mediated cardiac relaxation. However, emerging …
