cAMP is not an important messenger for ADP-induced platelet aggregation
P Savi, AM Pflieger, JM Herbert - Blood coagulation & fibrinolysis, 1996 - journals.lww.com
In rat platelets, basal cAMP level did not vary significantly during ADP-induced aggregation.
In the same conditions, no variation in the cAMP content was observed in platelets from rats
treated with clopidogrel, whereas ADP-induced aggregation was totally inhibited. ADP
decreased cAMP level in control prostacyclin-or forskolin-stimulated platelets whereas, in
treated platelets, adenylyl cyclase down-regulation was strongly inhibited. SQ 22536 (500
[mu] M), an inhibitor of adenylyl cyclase, strongly reduced the cAMP content of both control …
In the same conditions, no variation in the cAMP content was observed in platelets from rats
treated with clopidogrel, whereas ADP-induced aggregation was totally inhibited. ADP
decreased cAMP level in control prostacyclin-or forskolin-stimulated platelets whereas, in
treated platelets, adenylyl cyclase down-regulation was strongly inhibited. SQ 22536 (500
[mu] M), an inhibitor of adenylyl cyclase, strongly reduced the cAMP content of both control …
